Bilateral optic neuritis due to isoniazid (INH).
نویسندگان
چکیده
Optic nerve involvement is a rare side effect of isoniazid (INH) and has not been described in children. We describe this adverse reaction in a 10-year-old boy, who was treated for tuberculous meningitis. The patient showed almost complete resolution following withdrawal of INH and administration of pyridoxine and steroids.
منابع مشابه
A case with chronic renal failure involving ethambutol and isoniazid associated bilateral optic neuritis development
Ethambutol and isoniazid are antimicrobial agents used to treat multi-drug-resistant tuberculosis. The most commonly recognized toxic effect of these drugs is optic neuropathy, usually manifesting as a decrease in visual acuity, deficits in color vision and ceco central scotomas. Total visual loss is a rare complication that can be related to ethambutol and isoniazid toxicity. As precipitating ...
متن کاملبررسی یافته های MRI مغز در بیماران مبتلا به نوریت اپتیک
Background and purpose: Optic neuritis is one of the common causes of unilateral or bilateral visual loss. The most common cause of this disorder is demyelinating disease of the central nervous system (CNS) and most of the patients with optic neuritis will present other signs of multiple sclerosis (MS). The diagnosis depends on the clinical findings, however, magnetic resonance imaging (MRI) is...
متن کاملIsoniazid MIC and KatG Gene Mutations among Mycobacterium tuberculosis Isolates in Northwest of Iran
Objective(s) Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. Resistance to INH is mediated mainly by mutation in KatG gene that is coded for the catalase enzyme. The proportional method for detection of INH-resistance is time consuming due to the slo...
متن کاملKinetic Studies on Growth of Excised Root Tips of Lycopersicum esculentum.
When isonicotinic acid hydrazide (INH) was first used for therapy of tuberculosis many patients developed peripheral neuritis resembling that of pyridoxine deficiency. Such patients exhibited increased urinary excretion of pyridoxine; administration of pyridoxine prevented the neuritis (1). In vitro studies have confirmed that INH inhibits pyridoxinedependent bacterial decarboxylases and transa...
متن کاملKey community eye health messages
A swollen optic disc may be unilateral or bilateral • If associated with severe headache and relatively normal vision this probably indicates papilloedema due to raised intracranial pressure which requires urgent investigation and diagnosis. • If the vision is significantly reduced and there is no headache it is probably due to inflammation of the optic nerve (optic neuritis / papillitis) which...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Indian pediatrics
دوره 47 6 شماره
صفحات -
تاریخ انتشار 2010